Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents

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United States of America Patent

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12080357

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Abstract

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Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Methods of treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy.or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

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NANOTHERAPEUTICS INC13859 PROGRESS BOULEVARD SUITE 300 ALACHUA FL 32615

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Belcourt, Michael F Wallingford , US 2 2
Doyle, Terrence W Killingworth , US 42 242
King, Ivan North Haven , US 7 63
Lin, Xu Branford , US 14 45

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