Metabolic profile directed aptamer medicinal chemistry

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United States of America Patent

SERIAL NO

12150855

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Abstract

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The present invention provides materials and methods for enhancing aptamers. More specifically, the materials and methods of the present invention are directed toward the modification of aptamers by the identification of one or more cleavage sites, and introduction of a chemical substitution at a position proximal to the cleavage site(s). Such aptamers are useful for the treatment of disease, in diagnostic and detection applications, and/or research, e.g., target validation.

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Patent Owner(s)

Patent OwnerAddress
ARCHEMIX CORP300 THIRD STREET FIRST FLOOR CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cload, Sharon Cambridge , US 13 297
Donahue, Christine P Brighton , US 1 5
Hutabarat, Renta Winchester , US 9 13
Thompson, Kristin Arlington , US 13 341
Wilson, Charles Concord , US 82 1076

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