METHOD FOR PRODUCING A NUCLEIC-ACID-CONTAINING COMPLEX PREPARATION
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United States of America Patent
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Issued Date -
Mar 12, 2009
app pub date -
May 29, 2006
filing date -
May 30, 2005
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Abandoned
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Abstract
The present invention relates to a method of preparing a nucleic-acid-containing complex formulation which can be sterilized by filtration and administered intravenously to a human, and can retain stability of polynucleotides included in the nucleic-acid-containing complex formulation. The invention also relates to a method of preparing a nucleic-acid-containing complex formulation, comprising the following steps: mixing a solution comprising two separate single-stranded polynucleotides (for example, poly I and poly C) capable of forming a double strand and a solution comprising a cationic carrier or the ingredients thereof to form the cationic carrier, and performing a dispersion treatment on the mixture.
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