CATIONIC ALPHA-AMINO ACID-CONTAINING BIODEGRADABLE POLYMER GENE TRANSFER COMPOSITIONS
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United States of America Patent
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Issued Date -
Mar 12, 2009
app pub date -
Aug 22, 2008
filing date -
Aug 23, 2007
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Abandoned
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Abstract
The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as arginine or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.
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