METHOD FOR PRODUCING A MUCIN-TYPE GLYCOPROTEIN
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United States of America Patent
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Issued Date -
Mar 12, 2009
app pub date -
Feb 26, 2007
filing date -
Mar 3, 2006
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Abandoned
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Abstract
The present invention relates to a means for generating a mucin-type glycopeptide or glycoprotein on a large scale in yeast. Specifically, the invention relates to a method which comprises introducing into a yeast at least one selected from the group consisting of a gene encoding UDP-GalNAc synthetase, a gene encoding UDP-GalNAc transporter, and a gene encoding polypeptide:O-GalNAc transferase, and, if desired, a gene encoding a mucin-type glycopeptide; and producing a mucin-type glycoprotein having O-GalNAc by use of the yeast.
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