FORMULATIONS FOR ENHANCED MUCOSAL DELIVERY OF PYY
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United States of America Patent
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Issued Date -
Feb 26, 2009
app pub date -
Jul 10, 2006
filing date -
Jul 11, 2005
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Abandoned
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Abstract
Pharmaceutical formulations are described for enhancing mucosal delivery of peptide YY (PYY) to a mammal. A PYY dosage form is described that is suitable for multi-use administration. The PYY dosage form comprises a bottle containing an aqueous pharmaceutical formulation and an actuator effective intranasal administration of the formulation. The formulation comprises a therapeutically effective amount of PYY, a buffer to control pH, a water-miscible polar organic solvent and a chelating agent for cations. The PYY dosage form exhibits at least 90% PYY recovery after storage as used for greater than about five days.
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