Methods and compositions for the treatment of conditions related to gastric acid secretion
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United States of America Patent
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Issued Date -
Feb 19, 2009
app pub date -
Mar 3, 2005
filing date -
Mar 11, 2004
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Abstract
A method comprising orally administering to a mammal a proton pump inhibitor, or a pharmaceutically acceptable prodrug thereof, and a compound which modulates the activity of the MRP2 or other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug, is disclosed herein, said method being effective for the prevention or treatment of a disease or condition related to gastric acid secretion. This method applied to compounds which both inhibit and stimulate MRP2 activity or activity of other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug.Compositions, medicaments, and experimental results related thereto are also disclosed.
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