System and method for obtaining and maintaining high-resistance seals in patch clamp recordings
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United States of America Patent
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Issued Date -
Feb 19, 2009
app pub date -
Jun 6, 2008
filing date -
Aug 21, 2002
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Abandoned
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Abstract
The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.
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