Cell Permeability Assay in a Living Array of Multiple Cell Types and Multiple Layers of a Porous Substrate
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United States of America Patent
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Issued Date -
Feb 12, 2009
app pub date -
May 11, 2005
filing date -
May 12, 2004
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Abandoned
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Abstract
The present invention provides a device for determining drug efficacy on target cells comprising (1) a porous support (B) having first and second surfaces and at least one area with a plurality of through-going channels, wherein said area comprises on said first surface at least one region, which can be contacted with target cells, and said area comprises on said second surface at least one region comprising a layer of barrier cells presenting a significant barrier adhered to said second surface, wherein said region on the first surface is located opposite to said region on the second surface of the porous support (B), and wherein said layer of barrier cells provides a barrier for the passage of drugs, and (2) a support (A) comprising drugs, which can be contacted with the barrier cells of the porous support (B).
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