RNAi Medicine Having No Adverse Effects
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United States of America Patent
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Issued Date -
Feb 5, 2009
app pub date -
Jan 27, 2006
filing date -
Jan 28, 2005
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Abandoned
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Abstract
An RNAi reagent and a medicine that have no adverse effects such as interferon and/or cytotoxicity induction are provided.An shRNA used for sequence-specific RNA interference without interferon and/or cytotoxicity induction and a medicine and a reagent containing the shRNA are provided, such shRNA comprising a sense strand comprising a sequence homologous to a target sequence of the target mRNA and an antisense strand comprising a sequence complementary to the sequence of the sense strand and having an overhang comprising one or a plurality of G(s) at the 5′ end of the sense strand.
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