BIODEGRADABLE CATIONIC POLYMER GENE TRANSFER COMPOSITIONS AND METHODS OF USE

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United States of America Patent

APP PUB NO 20090029937A1
SERIAL NO

12177682

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Abstract

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The invention provides biodegradable, cationic compositions based on cationic α-amino acid-containing PEA, PEUR and PEU polymers for use in preparation of non-viral gene transfer compositions. In the invention gene transfer compositions a poly nucleic acid is condensed with the polymer to form a soluble unit wherein the electrical charge of the poly nucleic acid is neutralized by the polymers. The invention gene transfer compositions can be used to transfect target cells by contact with the target cells.

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Patent Owner(s)

Patent OwnerAddress
CORNELL UNIVERSITY395 PINE TREE ROAD SUITE 310 ITHACA NY 14850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chu, Chih-Chang Ithaca , US 48 1544
Gomurashvili, Zaza D La Jolla , US 19 443
Liu, Bo Roosevelt Island , US 672 3701
Mutschler-Chu, Martha A Ithaca , US 3 16
Song, Hua Ithaca , US 37 199

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