Expression signature in peripheral blood for detection of aortic aneurysm
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United States of America Patent
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Issued Date -
Jan 29, 2009
app pub date -
Oct 30, 2007
filing date -
Oct 31, 2006
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Abstract
We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.
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