Bispecific antibodies that bind to vegf receptors
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United States of America Patent
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Issued Date -
Jan 29, 2009
app pub date -
Dec 24, 2002
filing date -
Jun 26, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to production of antigen-binding proteins that bind specifically to an extracellular domains of two different VEGF receptors. The bispecific antigen-binding proteins block activation of the VEGF receptors and are used to reduce or inhibit VEGF-induced cellular functions such as mitogenesis of vascular endothelial cells and migration of leukemia cells. The antigen-binding proteins of the present invention can be monovalent or multivalent, have antigen-binding sites consisting of immunoglobulin heavy chain and light chain variable domains and may further include immunoglobulin constant domains.
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