AGENTS AND METHODS FOR INHIBITION OF AIRWAY HYPERRESPONSIVENESS
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United States of America Patent
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Issued Date -
Jan 29, 2009
app pub date -
Jul 24, 2008
filing date -
Jul 24, 2007
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Abstract
The present invention provides methods and compositions for inhibition of Airway Hyperresponsiveness (“AHR”) by deleting, inactivating or inhibiting a subset of innate γδ T cells, alone or in conjunction with the inhibition of Natural Killer T (“NKT”) cells. The methods comprise selective leukophoresis to remove the γδ T cells from the individual's blood or administration of an agent that selectively targets and inhibits or inactivates the γδ T cells. The methods of the present invention can be used to treat AHR in a variety of different ailments, including allergen-induced conditions or respiratory conditions and diseases.
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