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United States of America Patent
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Issued Date -
Jan 22, 2009
app pub date -
Oct 5, 2007
filing date -
Oct 18, 2003
priority date (Note) -
Abandoned
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Abstract
Opioid tolerance is reduced by treating the patient with a neurosteroid of formula (I) wherein R1 is H or methyl; R2 is OH and R3 is H, or R2 and R3 taken together are O; R4 is H or methyl; R5 and R6 are each H, or R5 and R5 taken together are O; R7 is H or methyl; and R8 is H, OH, —OC(═O)CH3, SH, —SC(═O)CH3, Cl, Br or F.
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