MODIFICATION OF DOUBLE-STRANDED RIBONUCLEIC ACID MOLECULES
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United States of America Patent
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Issued Date -
Jan 15, 2009
app pub date -
May 25, 2006
filing date -
Sep 2, 2005
priority date (Note) -
Abandoned
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Abstract
A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5′-methyl-pyrimidine and/or at least one 2′-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.
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