Use of Salicylate as an Antidote for Paraquat Intoxications in Mammals
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United States of America Patent
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Issued Date -
Jan 8, 2009
app pub date -
May 11, 2007
filing date -
May 12, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention concerns to the use of salicylate in the treatment of mammal intoxications caused by the herbicide paraquat (PQ). It was achieved, for the first time, 100% of survival 30 days after the administration to Wistar rats, by intraperitoneal route, of a PQ dose that, in the absence of treatment, is itself 100% lethal at the end of 6 days. The administration of salicylate, two hours after PQ, reversed the PQ toxicity and extended the life of the animals to the levels of the control group.
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