INTEGRASE FUSION PROTEINS AND THEIR USE WITH INTEGRATING GENE THERAPY

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United States of America Patent

APP PUB NO 20090011509A1
SERIAL NO

10586080

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Abstract

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In a method of targeting intergration of a transgene comprising retrovirus-like DNA into a eukaryotic genome, the genome is cleared by an endonuclease and the transgene is introduced at the site of cleavage, wherein the endonuclease is specific to a site in an abundant rDNA locus and is fused to an integrase that mediates the introduction of the transgene. The fusion protein may be new.

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Patent Owner(s)

Patent OwnerAddress
ARK THERAPEUTICS LTD1 FITZROY MEWS LONDON W1T 6DE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahlroth, Mervi Inkoo , FI 1 1
Airenne, Kari Kuopio , FI 4 7
Laitinen, Olli Kuopio , FI 14 7
Schenkwein, Diana Kuopio , FI 2 1
Yla-Herttuala, Seppo Kuopio , FI 55 396

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