Screening methods for compounds that modulate the activity of G-protein coupled receptors
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United States of America Patent
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Issued Date -
Jan 1, 2009
app pub date -
Jun 5, 2007
filing date -
Jun 7, 2006
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Abandoned
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Abstract
The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of said receptors for the identification of functional ligands is also encompassed.
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