Tumour vaccines for MUC1-positive carcinomas
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United States of America Patent
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Jan 14, 2008
filing date -
Dec 30, 1997
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Abstract
Embodiments of the invention provide tumour vaccines, especially for activation of glycopeptide-specific cytotoxic T-cells by MHC class I pathway, comprising at least one peptide of 8-11 amino acids derived from the region SAPDTRPAPGST of the human epithelial mucin MUC1 containing the immunodominant PDTRPAP region and which is glycosylated on threonine of the immunodominant PDTRPAP region and start with SAP, APD or PDT at it's N-terminus.
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