Protein Cleavage at Aspartic Acid Using Chemical Reagents
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United States of America Patent
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Issued Date -
Dec 25, 2008
app pub date -
Sep 14, 2005
filing date -
Sep 15, 2004
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Abstract
The present invention relates to the methods of identifying and quantifying polypeptides in a given sample by mass spectrometric analysis. More specifically, the invention provides the methods for sample preparation for proteomic analysis: the methods for the fragmentation of proteins into peptides with the specific cleavage rule (cleavage at amino-terminal or carboxyl-terminal of aspartic acid), which are suitable for the analysis by mass spectrometry apparatus.
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