Agent for Regulating Bone Formation
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United States of America Patent
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Issued Date -
Dec 18, 2008
app pub date -
Dec 15, 2005
filing date -
Dec 16, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides preventive, ameliorating, and/or therapeutic agents for diseases caused by a disturbed balance between bone formation and bone resorption. The decoys of the present invention induce normal bone metabolism by inhibiting the differentiation-inducing factors of cells involved in bone metabolism. For example, bone resorption can be controlled by using a decoy of the present invention to inhibit NF-.kappa.B, a transcriptional regulatory factor that regulates osteoclast differentiation. This method uses a mechanism different from those of previous pharmaceutical agents; therefore, one can expect it to be effective for cases in which existing pharmaceutical agents were not effective.
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