Antibody Binding Affinity Ligands
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United States of America Patent
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Issued Date -
Dec 18, 2008
app pub date -
Dec 23, 2005
filing date -
Dec 23, 2004
priority date (Note) -
Abandoned
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Abstract
The present application discloses a solid support material having covalently immobilized thereon an affinity ligand, said ligand comprising one or more hydrophobic functional group(s) and one or more cationic functional group(s) or one or more heteroaromatic functional group(s), wherein at least one hydrophobic functional group is separated from at least one cationic/heteroaromatic functional group by a through bond distance of from 5 .ANG. to 20 .ANG., wherein said ligand has a molecular weight of from 120 Da to 5,000 Da. Typically, the affinity resin has a binding capacity larger than 5 mg monoclonal antibody per mL of affinity resin. A method for the isolation of biomolecules, such as proteins, in particular antibodies, such as monoclonal antibodies, or derivatives thereof, is also disclosed.
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