Cyanoacrylate Adhesive Compositions and Devices and Process for Sterilization Thereof
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United States of America Patent
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Issued Date -
Dec 18, 2008
app pub date -
Jun 12, 2007
filing date -
Jun 12, 2007
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Abstract
Disclosed are processes for sterilization of cyanoacrylate adhesive compositions; the compositions, comprising 2-cyanoacrylate ester monomers, so produced and a method for assaying the effectiveness of the sterilization process. A typical process comprises heating the adhesive composition to from about 70.degree. C. to about 140.degree. C. for an effective amount of time. The effectiveness of a process can be assayed by disposing bacterial spores in the cyanoacrylate monomer, exposing the composition to a dry heat sterilization process, transferring the cyanoacrylate composition to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.
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