Multi-Layer Tablets and Bioadhesive Dosage Forms
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United States of America Patent
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Issued Date -
Dec 18, 2008
app pub date -
Aug 29, 2005
filing date -
Aug 27, 2004
priority date (Note) -
Abandoned
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Abstract
Bioadhesives coatings increase the gastrointestinal retention time of orally-ingested medicaments. Certain bioadhesive coatings producing a fracture strength of at least 100 N/m.sup.2, as measured on rat intestine, when applied to at least one surface of a pharmaceutical dosage form for oral delivery of a drug, result in a gastrointestinal retention time of at least 4 hours in a fed beagle dog model, during which the drug is released from the dosage form. Multi-layer tablets, particularly those including hydrophobic excipients, are useful in administering hygroscopic and/or deliquescent drugs. In addition, varying the amount of drug in multi-layer tablets allows the release rate of the drug to be controlled.
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