Marked Bovine Viral Diarrhea Virus Vaccines
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United States of America Patent
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Issued Date -
Dec 11, 2008
app pub date -
Nov 24, 2006
filing date -
Dec 7, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
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