Method for Producing Epidermal Growth Factor Using Fusion Proteins Comprising Fas-1 Domain
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United States of America Patent
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Issued Date -
Nov 13, 2008
app pub date -
Nov 3, 2005
filing date -
Nov 3, 2004
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Abandoned
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Abstract
The present invention provides a fusion protein in which a polypeptide comprising Fas-1 domain is fused in frame to N-terminal or C-terminal of human EGF, a nucleotide sequence encoding the fusion protein, an expression vector containing the nucleotide sequence, a transformant transformed by the nucleotide sequence and a method for producing human EGF, improving stability of the protein and enhancing the functions of the same. The present invention provides human EGF with improved stability and enhanced functions by fusing a polypeptide comprising Fas-1 domain having the activities of cell adhesion and wound healing to human EGF.
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