Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof
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United States of America Patent
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Issued Date -
Oct 30, 2008
app pub date -
Apr 24, 2008
filing date -
Apr 27, 2007
priority date (Note) -
Abandoned
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Abstract
The invention relates to a method for preparation of aminoaryl- or aminoheteroarylboronic acids and esters and salts thereof in which an optionally substituted aminoaryl or aminoheteroaryl compound is protected at its nitrogen site via condensation with a carbonyl compound, subsequently metalated and converted with a suitable boron compound. Depending on the subsequent work-up and removal of the protective group, the corresponding boronic acid, the anhydride or the boronic acid ester thereof is obtained
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