SUPERCRITICAL FLUID EXTRACTION PRODUCED BY IN-LINE HOMOGENIZATION

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United States of America Patent

APP PUB NO 20080260852A1
SERIAL NO

12017414

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Abstract

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A method for producing micro and/or nanoparticles by contacting an emulsion with a supercritical fluid. The method can be used to produce an aqueous suspension of particles that include a drug encapsulated in a polymer. The drug and polymer are dissolved in an organic solvent to form an organic solution. The organic solution is pumped into contact with an aqueous solution in an in-line homogenization device to form an emulsion. Immediately after the emulsion in the in-line homogenization device, the emulsion contacts the supercritical fluid. The supercritical fluid extracts the organic solvent from the oil droplets of the emulsion, causing the drug and polymer to precipitate into the aqueous phase of the emulsion and thereby form an aqueous suspension of particles that include a drug encapsulated in a polymer.

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Patent Owner(s)

Patent OwnerAddress
FERRO CORPORATION6060 PARKLAND BOULEVARD SUITE 250 MAYFIELD HEIGHTS OH 44124

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chattopadhyay, Pratibhash North Royalton, OH 25 598
Gibson, K Adam Fairlawn, OH 2 77
Shekunov, Boris Y Aurora, OH 23 520

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