Regulators of the hedgehog pathway, compositions and uses related thereto
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United States of America Patent
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Aug 16, 2011
Grant Date -
Oct 16, 2008
app pub date -
Mar 28, 2008
filing date -
Oct 13, 1999
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Abstract
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
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