Methods
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United States of America Patent
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N/A
Issued Date -
Oct 9, 2008
app pub date -
Dec 18, 2006
filing date -
Mar 4, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The production of genetically modified animals, in which the genetic modifications are engineered in somatic cells cultured in vitro by gene targeting, is described. Genetically modified cells may then used as nuclear donors to produce, inter alia, live animals. The methods described can also be used to validate loci in animal chromosomes which are suitable sites for transgene addition to cells.
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