Irta-2 Antibodies and Their Uses

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United States of America Patent

APP PUB NO 20080247944A1
SERIAL NO

11794606

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.

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Patent Owner(s)

Patent OwnerAddress
MEDAREX INCROUTE 206 & PROVINCE LINE RD PRINCETON NJ 08540

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cardarelli, Josephine M San Carlos, CA 69 2845
Graziano, Robert Frenchtown, NJ 24 985
Huang, Haichun Fremont, CA 121 4072
King, David J Belmont, CA 68 1246
Srinivasan, Mohan San Jose, CA 112 5838

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