Process For the Manufacture of Substituted Propionic Acids
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United States of America Patent
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Issued Date -
Oct 2, 2008
app pub date -
Jan 13, 2006
filing date -
Jan 14, 2005
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Abandoned
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Abstract
The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising a catalyst ligand having a metallocene group with a chiral phosphorus or arsenic substituent to provide in enantiomeric excess a product of formula (II): or its enantiomer or if applicable its diastereomer.
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