Anti-Inflammatory Agents
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United States of America Patent
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Issued Date -
Mar 27, 2008
app pub date -
May 14, 2007
filing date -
Sep 29, 2004
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Abandoned
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Abstract
We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I), wherein: R5 is OH, alkoxy or alkanoyloxy; R6 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R12 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R16 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R17 is OH, alkoxy or alkanoyloxy; R18 is OH, alkoxy or alkanoyloxy; R21 is H, OH, CN or another nucleophilic group; and Ra is hydrogen and Rb is optionally substituted amino, or Ra with Rb form a carbonyl function â•O, or Ra, Rb and the carbon to which they are attached form a tetrahydroisoquinoline group.
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