Compositions and methods for ameliorating hyperlipidemia
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United States of America Patent
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Issued Date -
Oct 2, 2008
app pub date -
Jun 1, 2007
filing date -
Jun 2, 2006
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Abstract
The invention provides compositions and methods for treating hyperlipidemia by administering a Microsomal Triglyceride Transfer Protein (MTP) inhibitor in combination with a Liver Fatty Acid-Binding Protein (L-FABP) inhibitor, methods of preventing the development of hepatic steatosis, methods of identifying an agent useful for treating hyperlipidemia, and methods of screening for inhibitors of MTP and L-FABP activity. Also provided are pharmaceutical compositions comprising a MTP inhibitor and a L-FABP inhibitor.
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