TREATMENT OF DISEASES WITH NANOPARTICLES HAVING A SIZE-DEPENDENT CYTOTOXICITY
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United States of America Patent
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Issued Date -
Oct 2, 2008
app pub date -
Apr 1, 2008
filing date -
Apr 2, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of at least one gold nanocluster compound in the manufacture of a pharmaceutical composition or medicament for the prophylactic and/or therapeutic (curative) treatment of a disease, especially a tumor and/or cancer disease. The gold nanocluster compound having a defined particle size, especially a defined size of the core of said gold nanocluster compound, the size ranging from 0.5 nm to 10 nm, the outer limits of this range being included. Especially, the gold nanocluster compounds used possess size-dependent cytotoxic properties, stimulating or inducing cellular death when treating and/or contacting respective cells, especially tumor and/or cancer cells, with the gold nanocluster compounds either via apoptosis or via necrosis, depending on the respective gold cluster size or core size.
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