Method for propagating adenoviral vectors encoding inhibitory gene products

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United States of America Patent

APP PUB NO 20080233650A1
SERIAL NO

12118008

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Abstract

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The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.

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Patent Owner(s)

Patent OwnerAddress
GENVEC INC65 WEST WATKINS MILL ROAD GAITHERSBURG MD 20878

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brough, Douglas E Gaithersburg, MD 85 1161
Gall, Jason G D Germantown, MD 24 139
King, C Richter Washington, DC 42 851

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