NANOPARTICLE ADJUVANTS FOR SUB-UNIT VACCINES
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United States of America Patent
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Issued Date -
Sep 25, 2008
app pub date -
Oct 19, 2007
filing date -
Apr 12, 2002
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Abandoned
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Abstract
The present invention relates to nanoparticle vaccine adjuvants comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in order to direct it to a specific site or cell type to optimize a desired immune response. The present invention also relates to encapsulating an antigen or combinations of different antigens within such nanoparticles, with or without a targeting molecule displayed on its surface. The antigens used in this invention are effective to produce an immune response against a variety of pathological conditions.
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