Assay for response to proteasome inhibitors
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United States of America Patent
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Issued Date -
Sep 18, 2008
app pub date -
Dec 7, 2007
filing date -
Dec 8, 2006
priority date (Note) -
Abandoned
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Abstract
The invention relates to a method for predicting a response to a proteasome inhibitor in the prophylaxis or treatment of a cancer in an individual. The method comprises providing a sample of cancer cells of the cancer from the individual, and evaluating the level of at least one molecule in the cancer cells associated with the unfolded protein response of the cancer cells, to provide test data indicative of the level of activity of the unfolded protein response. The test data is used to predict the response of the cancer cells to the proteasome inhibitor. The evaluation of the level of the molecule can be utilized for determination of treatment for the cancer.
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