Test System and Method for the Detection of Analytes
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United States of America Patent
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Issued Date -
Sep 18, 2008
app pub date -
Jan 31, 2005
filing date -
Jan 30, 2004
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Abandoned
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Abstract
The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a probe, preferably a nucleic acid or a nucleic acid derivative, coupled to a catalytic component, preferably an enzyme. The analyte induces a conformation change in the probe, which alters the accessibility for a substrate in the probe to catalytic components and the change in substrate turnover, corresponding to the change in catalytic activity, is measured.
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