Drug Release Cell and a Method for Testing the Drug Release of a Suspension in a Liquid Utilizing the Same
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United States of America Patent
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Issued Date -
Sep 18, 2008
app pub date -
Mar 13, 2007
filing date -
Mar 13, 2007
priority date (Note) -
Abandoned
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Abstract
A drug release cell useful in testing the drug release of a product in a liquid includes a first chamber and a second chamber with a membrane positioned in between such that the first chamber is located above the membrane and the second chamber is located below the membrane. The membrane has pores sized to permit a liquid and a released product, such as an insulin suspension, disposed in the second chamber to pass therethrough. When the drug release cell is filled with liquid and product is present in the second chamber the liquid is mixed with a mixing device to circulate the liquid and disperse released media throughout the liquid. Samples are taken at predetermined times from the first chamber through a sampling port to determine the concentration of the product in the liquid. The concentration data may then be utilized to create a drug release profile. Different formulations of a product may be tested in the drug release cell and the concentration data may be utilized to create distinguishable drug release profiles for each formulation.
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