Butyrylcholinesterase Variants that Alter the Activity of Chemotherapeutic Agents
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United States of America Patent
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Issued Date -
Sep 4, 2008
app pub date -
Dec 4, 2003
filing date -
Dec 4, 2002
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Abstract
The invention provides a butyrylchinesterase variant, a method of converting a camptothecin derivative to a topoisomerase inhibitor by contacting the camptothecin derivative with a butyrylcholinesterase variant and a method of treating cancer by administering to an individual an effective amount a butyrylcholinesterase variant exhibiting increased capability to convert a camptothecin derivative to a topoisomerase inhibitor compared to butyrylcholinesterase.
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