Decoy compositions for treating and preventing brain diseases and disorders
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United States of America Patent
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app pub date -
Nov 5, 2007
filing date -
Mar 29, 2002
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Abstract
The present invention provides introduction of NF-.kappa.B decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-.kappa.B decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor .alpha., interleukin 1.beta. and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-.kappa.B decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-.kappa.B decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.
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