Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols

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United States of America Patent

APP PUB NO 20080200672A1
SERIAL NO

11512599

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Novel spiroborate esters derived from non-recemic 1,2-amino alcohols were examined as chiral catalyst in the borane reduction of acetophenone and other aromatic ketones at room temperature. The optically active alcohols were obtained in excellent chemical yields and up to 99% ee with less than 10% catalyst.

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UNIVERSITY OF PUERTO RICOCARRETERA #1 ESQUINA CARRERTERA #8838 SECTOR EL CINCO SAN JUAN 00926 00926

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Inventor Name Address # of filed Patents Total Citations
Correa-Ramirez, Wildeliz Humacao, PR 2 4
Jesus, Melvin de Juncos, PR 1 2
Ortiz-Marciales, Margarita Humacao, PR 3 4
Stepanenko, Viatcheslav Humacao, PR 2 2

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