Methods For Suppressing Tumor Proliferation
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United States of America Patent
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Issued Date -
Aug 21, 2008
app pub date -
Mar 15, 2005
filing date -
Mar 16, 2004
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Abandoned
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Abstract
The present invention provides methods for suppressing tumor proliferation comprising the step of inhibiting the expression of PDGF-A or the binding between PDGF-A homodimers and PDGFR.alpha.. Activation of the PDGFR.alpha.-p70S6K signal transduction pathway by PDGF-AA is an important factor in tumor angiogenesis and relates to the prognosis of patients suffering from tumors. By inhibiting PDGF-A expression in tumors or in their surrounding tissues, or by inhibiting the binding between PDGF-A homodimers and PDGFR.alpha., the formation and retention of tumor vasculature can be inhibited, thereby suppressing tumor proliferation.
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