Methods of neuroprotection by cyclin-dependent kinase inhibition
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United States of America Patent
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Issued Date -
Jul 31, 2008
app pub date -
Dec 14, 2007
filing date -
Dec 14, 2006
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Abstract
The present invention relates to methods of suppressing neuronal death, such as is observed with ischemia-related diseases and disorders, including neuronal and cardiac conditions arizing from a sudden loss of oxygen and/or energy loss, and degenerative diseases, such as Alzheimer's disease to name just one. The methods involve the use of inhibitors that act primarily in a simultaneous manner on the cyclin-dependent kinases, CDK4 and CDK6.
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