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Abstract

A method of inhibiting or effecting the activity of an integral receptor which comprises contacting an integrin with a compound of formula I, or a pharmaceutically acceptable salt thereof; General Formula I Wherein the ring may be of any configuration; Z is sulphur, oxygen, CH.sub.2, NH, NR.sup.A or hydrogen, in the case where Z is hydrogen then R.sup.1 is not present, R.sup.A is selected from the set defined for R.sub.1 to R.sub.5, X is oxygen or NR.sup.A providing that at least one X of General Formula I is NR.sup.A, X may also combine independently with one of R.sub.1 to R.sub.5 to form an azide, R1 to R5 are independently selected from the group comprising H, --(CO)R.sub.6 or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, wherein R.sub.6 is selected from the group comprising an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, with the proviso that XR.sub.2 or XR.sub.3 or XR.sub.4 or XR.sub.5 is not NH.sub.2, with the further proviso that not more than one of R2 to R5 is hydrogen, where the group X is NR.sup.A and R.sup.A is not hydrogen, the groups R.sup.A and the corresponding group R.sub.2 to R.sub.5 may combine to form a cycle.

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First Claim