QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION
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United States of America Patent
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Issued Date -
Jul 24, 2008
app pub date -
Oct 12, 2007
filing date -
Oct 12, 2006
priority date (Note) -
Abandoned
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Abstract
Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
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