COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE
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United States of America Patent
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Jul 17, 2008
app pub date -
Dec 28, 2007
filing date -
Dec 28, 2006
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Abstract
The present disclosure provides amide-based, non-nucleoside compounds having an inhibitory activity against endogenous polymerases, such as polymerase alpha and polymerase gamma. This disclosure further provides uses of treating hyperproliferative diseases or disorders, such as benign or malignant neoplasms, and more specifically cancers that are sensitive to inhibition of polymerase alpha and polymerase gamma.
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