5-Amino-4-Hydroxy-2-Isopropyl-7-[4-Methoxy-3-(3-Methoxypropoxy)Benzyl]-8-M-ethylnonamides
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United States of America Patent
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N/A
Issued Date -
Jul 10, 2008
app pub date -
Dec 9, 2005
filing date -
Dec 10, 2004
priority date (Note) -
Abandoned
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Abstract
Compounds of the general formula (I) in which R is heterocyclyl which is bonded via a carbon atom and is mono- or polysubstituted by C.sub.1-6-alkyl, trifluoromethyl, nitro, amino, C.sub.1-6-alkylamino, di-C.sub.1-6-alkylamino, C.sub.2-6-alkenyl, C.sub.2-6-alkynyl, C.sub.1-6-alkoxy, C.sub.1-6-alkylcarbonyloxy, C.sub.0-6-alkylcarbonylamino, C.sub.1-6-alkoxycarbonylamino, hydroxyl, halogen, oxide, cyano, optionally N-mono- or N,N-di-C.sub.1-8-alkylated carbamoyl, optionally esterified carboxyl or C.sub.1-6-alkylenedioxy, or is substituted by oxo and mono- or polysubstituted by C.sub.1-6-alkyl, trifluoromethyl, nitro, amino, C.sub.1-6-alkylamino, di-C.sub.1-6-alkylamino, C2-6-alkenyl, C.sub.2-6-alkynyl, C.sub.1-6-alkoxy, C.sub.1-6-alkylcarbonyloxy, C.sub.0-6-alkylcarbonylamino, C.sub.1-6-alkoxycarbonylamino, hydroxyl, halogen, oxide, cyano, optionally N-mono- or N,N-di-C.sub.1-8-alkylated carbamoyl, optionally esterified carboxyl or C.sub.1-6-alkylenedioxy, and salts, especially pharmaceutically usable salts have renin-inhibiting properties and can be used as medicaments.
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